Surpass Topical Cream for Horses 124gm

 
 
Prescription Required
$84.19
ITEM OUR PRICE
Surpass Topical Cream for Horses 124gm

$84.19

Available. Usually Ships in 2 to 4 business days.

Shipping weight = 0.25 lb.

All medications are filled by Pet's Choice Pharmacy. More information. Can only be shipped to the 50 US states.
Save item

Product Summary:

Surpass Topical Cream for Horses 124 gram

RX Only

Prescription items are NON-RETURNABLE and NON-REFUNDABLE

Surpass Topical Cream is indicated for the control of pain and inflammation associated with osteoarthritis (OA) in tarsal, carpal, metacarpophalangeal, metatarsophalangeal and proximal interphalangeal (hock, knee, fetlock and pastern) joints in horses.

sage: Apply a five-inch (5") ribbon of Surpass topical cream twice daily over the affected joint for up to ten days.

Surpass topical cream contains 1% diclofenac sodium. Diclofenac is a non-steroidal anti-inflammatory drug of the phenylacetic acid class. The chemical name for diclofenac is sodium [o- (2,6-dichloroanilino)phenyl]acetate. The empirical formula is C14H10Cl2NNaO2 and the molecular weight is 318.13. Surpass topical cream contains 1% diclofenac sodium in a base composed of Phospholipon 90H, propylene glycol, alcohol (5.94%), vitamin E acetate, benzethonium chloride and purified water in the Wisdom® liposomal formulation.

Administration: Wear rubber gloves to prevent absorption into the hands. Rub the cream thoroughly into the hair covering the joint until it disappears.

In a controlled field study, 82 horses with osteoarthritis were treated with Surpass™ topical cream (42 horses) or placebo (40 horses). Lameness examinations were performed in horses with osteoarthritis associated with the tarsal, carpal, metacarpophalangeal, metatarsophalangeal and proximal interphalangeal joints. Investigators were masked to treatment. Investigators and owners were instructed to apply the test article over the affected joint twice daily (BID) for five days. Actual doses received by individual horses were calculated using tube weight measurements. The mean dose applied during the study was 73 mg per application. Average lameness scores showed statistically significant improvement following treatment with Surpass topical cream.

One diclofenac-treated horse developed colic and responded to symptomatic treatment on day four of the study. Day five bloodwork for the horse that colicked showed decreases in RBC, Hb and HCT, with an increase in PMNs, compared to pretreatment values. One placebo-treated horse exhibited mildly jaundiced mucous membranes on day five. No other adverse reactions were noted during the study.

Animal Safety

A controlled safety study was conducted with Surpass topical cream. Four groups of six healthy adult horses received 0, 0.6, 1.7 or 2.8X the recommended daily dose for twenty-eight days. The daily dose was divided into two applications on day one of the study. For the remainder of the study, the entire daily dose was given at one time on 0, 1, 3 or 5 joints (tarsal, carpal, metacarpophalangeal, metatarsophalangeal, and proximal interphalangeal joints), depending on the dosage group. The control group of six horses was sham-dosed by rubbing the joints daily for twenty-eight days. An additional study group evaluated six horses that received 5.6X the recommended daily dose of Surpass topical cream distributed over five joints on a single day. This dose group was observed for fourteen days without additional treatment.

Clinical examinations, hematology, serum chemistry, synovial fluid analyses, gross necropsy and histopathology were performed. At necropsy, one horse in the 5.6X group had a glandular gastric ulcer. A horse in the 2.8X group had diarrhea and uterine discharge throughout the study. Four of the six horses in the 5.6X group lost weight during the study.

Dose-dependent increases in diclofenac plasma concentrations were detected in horses in the 1.7X and 2.8X treatment groups.

 

Item Number Model Number UPC
PX101185 012IDX01-124 012313449810

Customers Also Bought

Product Image for Natural Horse Vet Bug Check
Natural Horse Vet Bug Check
From
$126.19
Regularly
$53.99
Savings
0%
View Details
SEE ALL OPTIONS
Product Image for Gatsby Replacement Halter Crown Piece
Gatsby Replacement Halter Crown Piece
From
$11.99
Regularly
$15.99
Savings
25%
View Details
SEE ALL OPTIONS
Product Image for Defender Long Nose Fly Mask with Ears
Defender Long Nose Fly Mask with Ears
From
$11.55
Regularly
$34.99
Savings
67%
View Details
SEE ALL OPTIONS
Product Image for Ivermectin Single Dose Wormer (1.87)
Ivermectin Single Dose Wormer (1.87)
Price
$7.99
Regularly
$8.99
Savings
11%
View Details
Product Image for Ariat Ladies Primetime Boots
Ariat Ladies Primetime Boots
From
$199.95
Regularly
$199.95
Savings
0%
View Details
SEE ALL OPTIONS
Product Image for Rescue Disposable Fly Trap
Rescue Disposable Fly Trap
From
$5.24
Regularly
$7.99
Savings
34%
View Details
SEE ALL OPTIONS
Product Image for Farnam TRI-Care Wound Treatment
Farnam TRI-Care Wound Treatment
Price
$14.99
Regularly
$19.99
Savings
25%
View Details
Product Image for Prascend Pergolide Tablets 1mg
Prascend Pergolide Tablets 1mg
From
$180.38
Regularly
$188.88
Savings
5%
View Details
SEE ALL OPTIONS
Product Image for Shires Deluxe Comfort Grazing Muzzle
Shires Deluxe Comfort Grazing Muzzle
From
$39.59
Regularly
$39.99
Savings
1%
View Details
SEE ALL OPTIONS

Product Reviews by Customers

Browse Questions and Answers

Sometimes, manufacturers require that products be advertised only at their suggested prices. When we choose to sell these items for less, we display the sale price only in the cart. To see the price, click Add to Cart.
By Continuing to use our site, you consent to our use of cookies to improve your experience. Learn more