Xylazine/Anased/Rompun 100mg/ml 50ml Vial

Careful consideration should be given before administering to horses and Cervidae with significantly depressed respiration, severe pathologic heart disease, advanced liver or kidney disease, severe endotoxic or traumatic shock and stress conditions such as extreme heat, cold, high altitude or fatigue. Do not use Xylazine HCl Injection (xylazine) in conjunction with tranquilizers. Analgesic effect is variable, and depth should be carefully assayed prior to surgical/clinical procedures. Variability of analgesia occurs most frequently at the distal extremities of horses and Cervidae. In spite of sedation, the practitioner and handlers should proceed with caution since defense reactions may not be diminished. Horses: Since an additive effect results from the use of Xylazine HCl Injection (xylazine) and the barbiturate compounds, it should be used with caution with these central nervous system depressants. Products known to produce respiratory depression or apnea, such as thiamylal sodium, should be given at a reduced dosage and, when injected intravenously, should be administered slowly. When intravenous administration of Xylazine HCl Injection (xylazine) is desired, avoid perivascular injection in order to achieve the desired effect. Studies have shown negligible evidence of tissue irritation, however, following perivascular injection of xylazine. Intracarotid Arterial Injection Should Be Avoided. As with many compounds, including tranquilizers, immediate violent seizures followed by collapse may result from inadvertent administration into the carotid artery. Although the reaction with Xylazine HCl Injection (xylazine) is usually transient and recovery may be rapid and complete, special care should be taken to assure that the needle is in the jugular vein rather than the carotid artery. Bradycardia and arrhythmia in the form of incomplete atrioventricular block have been reported following xylazine administration. Although clinically the importance of this effect is questioned,1,2,3,4 a standard dose of atropine given prior to or following xylazine will greatly decrease the incidence. Sedation for transport is most successful if actual transportation is begun after the full effect of the drug has been reached and the animal's stability is maintained while standing. In addition, it should be noted that animals under the influence of xylazine can be aroused by noise or other stimuli and this may increase the risk of injury. Cervidae: As in all ruminants, it is preferable to administer Xylazine HCl Injection (xylazine) to fasted Cervidae as a safeguard against aspiration of food material into the lungs and/or bloat during deep sedation. Care should be taken to administer Xylazine HCl Injection (xylazine) in the heavy muscles of the croup or shoulder. Injections given subcutaneously, intraperitoneally or into fat deposits will give unpredictable results. Intra-arterial injection should be avoided, as with many compounds, including tranquilizers, immediate violent seizures followed by collapse may result from inadvertent administration into an artery. The animal should not be disturbed during induction or until the full effect of the drug has been reached which is usually 10 to 15 minutes following injection. The usual time to initial effect of the drug is 2 to 5 minutes. The administrator of the drug should be fully cognizant of this interval prior to administration of drug to free-ranging deer or elk, especially at night or in heavily wooded areas. If the animal has been underdosed (faulty injection or miscalculation on weight) it is advisable to wait one hour before administering a second dose. Adequate ventilation- especially in cages or crates- is mandatory; keep head and neck in position to insure patient air passage and to prevent aspiration of stomach contents. During sedation, animals should be prevented from assuming lateral recumbency. A sternal recumbent position is desirable. While under the effects of Xylazine HCl Injection (xylazine) the animal should be protected from extreme hot or cold environments. Efforts should be made to prevent patient from rising until almost complete recovery is attained. The transportation of Cervidae given Xylazine HCl Injection (xylazine) should be carefully monitored to prevent excessive struggling, injury or death. Hyperthermic reactions may occur, especially if the subject is in a highly excited state when the drug is administered. Hosing the head and entire body with cold water has usually proven to be an effective deterrent. The safety of Xylazine HCl Injection (xylazine) has not been demonstrated in pregnant Cervidae. Avoid use during the breeding season. Cervidae should be observed closely until all of the sedative effects of Xylazine HCl Injection (xylazine) are gone. Care should be taken at all times when administering Xylazine HCl Injection (xylazine) to Cervidae. This is due to the method of administration (usually darting), the difficulty in estimating body weights and the accepted theory that wild animals are more unpredictable in their response to sedatives and analgesics than the domesticated species.